Built environments that are more sustainable need to be developed urgently. Climate change also means that buildings and urban environments must be resilient to unpredictable weather conditions. However, concepts of sustainability and resilience often appear to be in conflict. Sustainability aims to drive change to a more positive future while resilience seeks to maintain the functionality of existing systems. This conflict must be understood and managed to achieve sustainable development efficiently. This paper describes the development of the Resilient Sustainability Measurement and Evaluation (RESUME) framework that aims to integrate sustainability and resilience in an assessment tool for neighbourhoods. The study presents RESUME and applies this to a case study in Pretoria, South Africa. Findings from the study indicate that the RESUME approach provides a valuable way of addressing sustainability and resilience at a neighbourhood level and recommends developing this further.