This research examines how a data-led approach to estate utilisation and performance can unlock capacity and inform prioritisation for the UK Higher Education (HE) sector amidst five critical megatrends: climate change, demographic shifts, urbanisation, digital technologies, and inequality. The sector faces financial instability due to a decade-long freeze on tuition fees, rising operational costs and increasing reliance on international student income now impacted by changes in visa policies. Contextual analysis is used to set out the scale of the challenge and opportunity, emphasising the significant emissions from university buildings, and a novel data-driven approach is used to offer an in-depth evaluation of opportunities to drive improvement at a UK teaching University, which has relevance at both sector and cross-sector level. The study highlights potential carbon savings through improved building management and retrofitting existing buildings rather than new construction. The research underscores the importance of understanding and linking space utilisation with building performance and energy use to meet decarbonisation goals and financial constraints. The study emphasises the need for estate owners to understand their existing assets before building more space if they are to address economic and operational challenges and meet sustainability targets. By actively monitoring space use, adopting active energy management practices and prioritising the internal environment for health and wellbeing, universities can reduce their environmental impact while remaining financially viable and relevant in addressing global issues.