Drug-induced pancreatitis (DIP) is a rare cause of acute pancreatitis, with the majority of cases ranging from mild to moderate, including severe and fatal. The management of DIP requires the withdrawal of the offending agent and supportive care. Cyclosporine is one of the immunosuppressive agents that is still under investigation regarding its association with acute pancreatitis. In this case, a 63-year-old male patient presented with septic shock due to acute pancreatitis, confirmed by elevated serum lipase and amylase. The patient had a history of Myelodysplastic Syndrome (MDS) and was treated with cyclosporine.