In neutrino oscillation experiments, massive nuclear targets are used to increase the number of neutrino interactions and improve statistical accuracy, but this introduces systematic uncertainties due to the complex nuclear environment. The interaction of neutrinos with nuclear targets results in an imprecise neutrino energy reconstruction and cross-sectional uncertainties, which affect the measurement of oscillation parameters. Therefore, understanding the neutrino-nucleus interaction and accurately reconstructing the neutrino energy are crucial for the precise measurement of oscillation parameters. In this work, we studied these uncertainties in the Quasi-Elastic (QE) interactions by analyzing events with one proton, zero pions, and multiple neutrons for DUNE and MicroBooNE experiments. Using these specific interactions, we applied the calorimetric methods for neutrino energy reconstruction. Our analysis shows the critical role of proper event selection for accurate neutrino energy reconstruction, and the potential of calorimetric methods for precision physics in neutrino experiments.