Fuman Oilfield is the largest ultra-deep (7500–loration and development enter the stage of detailed description, the main focus of research is on medium to small-scale fractured-vuggy reservoirs (FVRS). Due to the influence of complex geological velocity errors, there are errors in the spatial imaging positions of FVRS, which become the most important factor in the success or failure of drilling. This article proposes an efficient optimization method for drilling trajectory based on VSP-seismic geological guidance while drilling. By utilizing the waiting time before drilling, a Zero Offset VSP (vertical ground) measurement is carried out to obtain accurate formation velocity, Q value, and anisotropy parameters. The migration velocity field and anisotropy field are updated to support fast and effective imaging of approximately 30 square kilometers of data. Then, fine reservoir prediction is carried out to determine the target position, and finally, trajectory optimization adjustment is implemented to drill into the target. The application has shown that this technology has achieved good results in the exploration and development of strike-slip fault controlled reservoirs. The drilling experience of the reservoir after adjusting the trajectory has been greatly improved, effectively promoting the implementation of low-cost and cost-effective development plans in the oilfield.