The differences in the spatial structure of fault-controlled karst systems restrict the efficient development of such reservoirs. Taking the FI17 fault zone in Fuman Oilfield as an example, comprehensive seismic structure interpretation, reservoir prediction, drilling and production information, the spatial structure difference of strike-slip faults is based on the fault-karst reservoir scale, fault activity difference, and fault segmentation of static data. The unit pressure drop and fluid production volume and connectivity analysis of dynamic data are comprehensively considered, and quantitative and qualitative analysis is carried out to finally select the advantageous target areas for controlling reserves and guide the deployment of efficient well locations. The results show that the areas with large-scale reservoir development are the dominant control-reservoir targets for strike-slip faults. The connectivity of the stretched segment of the strike-slip fault is better than that of the pressure-uplift segment and the linear segment, and some suggestions for efficient well placement in the FI17 fault zone are put forward. For tension-torsional faults with good connectivity between segments, we recommend that the wells be deployed in a way of separate control and high production with few wells. For the compression-torsional fractures with strong separation in the compression-uplift section, our suggestion is to produce multiple targets in one well with high efficiency. The research results can be used as a reference for improving the theoretical understanding of fault-controlled karst systems and guiding the practice of reservoir development.