In order to further accelerate the process of natural gas exploration and development in Liangjiashan Formation of Yangshuiwu buried hill, the sweet spots of natural gas occurrence is sought. The prediction method of geological engineering is established on the basis that lithology is the main control factor of geological sweet spots and brittleness index and rupture pressure is the main control factor of engineering sweet spots. In terms of geological sweet spots, the dominant lithology of natural gas sweet spots is dolomite through core, experiment, drilling and logging data, etc. Based on log calculation curve and whole rock mineral analysis, the distribution range of dolomite is described by reservoir prediction technology. In engineering sweet spots, the brittleness index body of the study area is obtained by inverting the Young's modulus and Poisson's ratio and using Rickman brittleness index method. Based on the actual fracturing pressure and the fracturing pressure curve calculated by logging, the fracturing pressure body in the study area is obtained by inversion. The prediction results are in agreement with the measured drilling results, which confirms the accuracy of the prediction of the geological engineering sweet spots and can effectively provide a reference for the exploration of carbonate gas reservoirs.