In view of the problems of strong water sensitivity, poor oil-bearing property, thin thickness and narrow channel of the S0 formation reservoir in Daqing placanticline oilfield, the Xing3 block in xingbei development area of placanticline oilfield is taken as an example, by using the comprehensive interpretation data of well logging, laboratory experiment and coring well, the attribute parameters with the highest correlation with oil-bearing property and water sensitivity are identified through two-step synergetic sensitivity attribute analysis, then, combined with the attribute parameter range, using the well-seismic joint inversion technology based on the waveform characteristic indication, the weak water-sensitive high oil-bearing high-quality reservoir of sazero group is accurately predicted, and the well location is guided. The results show that the combination of acoustic wave and resistivity can distinguish oil layer, poor oil layer and non-reservoir, and gamma can distinguish water sensitivity, the core analysis data show that the water sensitivity index of the well is 0.62, which is medium to strong water sensitivity, the oil-bearing grade is mainly oil-soaked and oil-bearing, the oil saturation is 61.4% on average, and the inversion result is accurate and reliable, the average daily output of oil is 3.5 t and the accumulative output is 1090.6 t. The effect of putting into production is better. The research results lay a foundation for the development of S0 group, and are of great significance for high-quality and stable production in Daqing Field.