There are abundant oil and gas resources around the central paleo-uplift in Sichuan Basin, and recent E&P practices show that deep formation pressure analysis of Dengying Group is significant. Based on the review of formation pressure prediction methods such as Eaton, Fillipone and Bowers, this paper conducts adaptability analysis and optimization of these methods, so as to implement the three-dimensional formation pressure prediction in the Pengtan-1 well area in central Sichuan Bain. The parameters of the three mentioned models above are optimized based on the well logging data, mud weight log and measured pressure data of Pengtan-101 Well, and then it is found that the pressure gradient predicted by the Bowers method has the best agreement with the measured pressure data samples. This optimized model is proved to be suitable as an effective method for predicting formation pressure in the Dengying Formation for Pengtan-1 area after it is applied to serval wells and consistent prediction results are obtained. Pressure prediction combined with three-dimensional seismic inverted velocity volume shows that the formation pressure gradient of the Deng-2 Member in the Pengtan-1 well area is spatially heterogeneous. It is generally higher in the northwest and relatively lower in the southeast within the area of interest. The pressure gradient ranges between 1.1–1.3, which is almost in a hydrostatic pressured state or a weakly over-pressured state, and the vertical distribution of pressure gradient has a certain inheritance. The study results provide significant reference for regional geomechanical analysis and oilfield development plan preparation.