Extremely tall asymmetrical buildings in places with strong winds are susceptible to devastating lateral loads. A comprehensive wind analysis of a U plan shaped building is described here, which involves four interfering buildings with square floor plans placed at a T shaped pattern. The 1:300 scaled U shape building with length, width and limb width of 150 mm, 250 mm and 50 mm is analysed in the Ansys CFX module considering Computational Fluid Dynamics (CFD) for isolated and interference conditions. The interference condition is formed by arranging the square buildings of 150 mm at 300 mm distance from the primary building in T shaped pattern. The height of both primary and interfering buildings is kept at 500 mm. The wind angle from 0° to 360° at 30° intervals is considered to assess the wind effect on the building. The validation and mesh refinement study is carried out to produce reliable information. A detailed comparison of flow streamlines, pressure and force coefficient of isolated and interference conditions has been made. The interference factor of pressure has been computed. A significant variation of flow streamlines has been observed since the interfering buildings restrict the wind flow. This causes a huge variation in force and pressure coefficients. The interfering buildings produce suction on the building faces where the positive pressure has been measured in isolated conditions. This variation indicates the careful design of clad elements.