The abstract should summarize the contents of the paper in short terms, i.e. 150–250 words Early and accurate diagnosis of the Familial Alzheimer’s Disease (FAD) is critical for effective treatment of this genetically inherited form of Alzheimer’s disease. A prediction of FAD from gene expression data is investigated and the performance of various machine learning models on the discovered patterns is evaluated. We compare the output of Linear, Ridge Regression and a LightGBM model with hyper-tuned parameters on data from the Gene Expression Omnibus. The LightGBM model is then hyperparameter tuned to better capture the non-linear complexity of the data. To find the predictive performance, a model is evaluated using MSE, R squared and accuracy. The results show that both the LightGBM model and the traditional models have lower MSE, higher R squared and better accuracy. By examining FAD data on high-dimensional gene expression data these results show that when dealing with high-dimensional gene expression data, sophisticated machine learning models perform better than other approaches, such as LightGBM show higher diagnostic accuracy in FAD. It is shown in this research the power of machine learning is immense and is a powerful tool for the predictive modeling of Alzheimer’s Disease, as well as possible early detection and personalized treatment. Future work might also aim to further improve model performance with other more complex genetic datasets.