This study investigates the interaction between shock waves and deposited radioactive particles in nuclear reactor containment buildings, where hydrogen combustion can occur, generating shock waves during severe accidents. Experiments involved depositing metal oxide particles and placing those metal strips inside a shock tube. Shock waves induce vortices, causing lifting and horizontal motion of particles, influenced by shear stress and reflected shock waves. High-speed cameras captured the resuspension process, and analysis was performed using Photoshop tools to understand particle behavior. In the experiment, the shock wave interaction maintains the front profile of the deposited layer, while front-face particles experience lifting and horizontal motion due to contact with post-shock flow. Downstream particles are subject to shear-driven vortices, initiating their lifting. The shock wave’s impulsive nature accelerates particles significantly. Increasing shock wave strength intensifies shear vortices, rotating non-spherical particles. Particle rolling determines lifting, and the vertical resuspension profile correlates with Mach number.