A complex numerical simulation was conducted to assess the response of a volatile, condensed phase chemical subjected to an explosive environment. The chemical was aerosolized via an explosive-driven, directed-spray dissemination device. Then a primal high explosive (HE), placed one meter away, was ignited and the blast wave interacted with the dispersed chemical. Some chemical was burned in the chamber, while some material exited the chamber via a roof vent and allowed to continue evolving at atmospheric conditions. The numerical prediction of the event was conducted using a multi-phase compressible/near-incompressible code. The code has the volume of fluid (VOF) methodology, the Eulerian/Lagrangian methodology, droplet breakup modeling, multi-step finite-rate chemical kinetics, etc. The numerical prediction was successfully conducted, and the results agreed well with the measured pressure and temperature on the chamber wall, and with the vented chemical mass outside the chamber.