Due to high construction efficiency and quality, Modular integrated Construction (MiC) buildings have been widely used and favored by designers. However, in addition to structural performance and economical aspects of MiC structures, modular standardization and industrial manufacturing are also important aspects which should be considered in the design process. In the current paper, an intelligent optimization design method is proposed to address this issue. A scheme is proposed considering the standardization of components and modular units, and a hybrid intelligent genetic algorithm is adopted to facilitate the optimization design process. Based on the proposed method, a MiC case is investigated and designed considering both structural performance and modular standardization., and the effectiveness of the proposed method is validated.