Previous research showed that the spatial variation of excitations is a primary cause of poundings in straight bridges. For skewed bridges, the occurrence of poundings can amplify the in-plane girder rotations, thus increasing the likelihood of girder dislocation. Understanding the effect of spatially varying excitations on the seismic behaviour of skewed bridges including poundings is crucial for bridge integrity. However, most previous research on skewed bridges has been conducted numerically. To gain a more realistic insight, large-scale experiments using three shake tables were performed on bridge models. The results due to uniform base excitations were considered as a reference. To reveal the influence of skew angle, a straight bridge and bridges with 30° and 45° angles were considered. Results revealed that ignoring spatially varying excitations will underestimate the bending moment at pier supports and girder displacements in both longitudinal and transverse directions.