The building and infrastructure industry substantially contributes to global energy consumption and greenhouse gas emissions. The annual increasing construction and demolition waste (CDW) contributes to a negative environmental impact worldwide that cannot be overstated. Current solutions to decrease CDW focus on recycling demolition waste materials. However, the environmental benefits of recycling demolition waste materials are controversial due to the energy consumption in material secondary processing and the material quality downgrade. Apart from material recycling, scholars have proposed the Design for Adaptability (DfA) concept, which aims to allow partial changes in structural function after some years. Hence, clients and engineers may avoid the total demolition of the structures and adapt them to new functional needs by making localized design changes. However, DfA conflicts with the architect's perception of structures’ static nature, which impedes DfA application. Design for deconstruction and reuse of structural elements (DfDR) is an innovative concept developed from prefabricated construction, CDW recycling techniques, and DfA. DfDR enables the reuse of structural elements through demountable connections. DfDR structures assemble precast structural elements on-site, allowing the addition or removal of components to fulfill the latest structure functional requirements. The disassembled elements can be reused in new structures to reduce the CDW generation. This work proposes a novel demountable column-to-column connection that can be used in the shear wall system with boundary columns, allowing shear walls to be easily disassembled into CFST columns and inner wall panels and reused at the end of their current structural life. The axial compressive performance of the connection has been validated through numerical analysis. The ultimate strength capacity, failure mode, and ductility of the proposed CFST column-to-column connection have been investigated. A suite of parametric studies has been conducted to investigate the effects of various parameters on the behaviour of the newly developed connection.