High-entropy alloys (HEA) have shown considerable promise from both a scientific and an application perspective in deep space exploration due to their outstanding comprehensive properties, including high strength, thermal stability and wear resistance. The phase composition, microstructure, mechanical properties and tribological performance of FeCoCrNiCu samples produced by laser cladding to explore a simpler approach to improve the lifespan of spatial motion mechanisms. The results show that the HEA coating is composed of the FCC phase, precipitating a small amount of Cu element at the grain boundary. Compared to the substrate, the microhardness of HEA coating has increased because of the solid solution strengthening caused by lattice distortion. Meanwhile, the HEA coating also shows an eye-catching friction performance, which is mainly derived from the segregation of Cu elements.