Genomic tree improvement using genomic selection (GS) is gaining momentum in forest tree improvement programs. In addition to being cost-effective and time-efficient, GS helps in selecting the good seeds and retaining promising seedlings, in better use of land aiming at more yield per unit area with a better adapting variety. Teak is an economically important timber tree offering substantial contribution to sustainable and ethical production of wood. Production of commercial teak plantations using clonal propagation methods is well practiced. Selection of elite genotypes using genomic information can only enhance the long-term economic output from these plantations. With a draft genome available, teak is considered as the best candidate for GS in tropical forestry. Use of GS with early phenotyping and appropriate propagation/breeding techniques leads to substantial improvement in genetic gain. Identification of genomic regions involved in economically important traits such as lignin synthesis, production of secondary metabolites, durability, and flower formation helps in genomic breeding program of teak by coupling it with the selection process. Additionally, traits that can be measured more directly such as the height, girth at breast height, specific gravity of wood, and color of wood can be used as proxy traits for GS of economically profitable trees for long-term gain. GS will be more effective with advanced high-resolution phenotyping for anatomical and chemical traits. In this chapter, we provide guidance on conducting GS for increased economic returns from teak plantations.