Agricultural productivity is constantly challenged by biotic and abiotic stresses. However, conventional plant breeding methods have previously been utilized to address these setbacks. With the advent of genome editing technologies, such as TALENs, ZFN, and CRISPR/Cas9, scientists can now precisely modify the genetic makeup of crops to introduce stress-resistance traits. Apart from the diverse site-directed nucleases that were accessible over a decade ago, the CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein) method of genome editing has garnered attention due to its cost-effectiveness, ease of use, versatility, and simplicity. Genetic engineering and biotechnology are poised for a true revolution thanks to the development of genome editing techniques. In addition to enabling research into the basic principles of biological systems, targeted editing of living organisms’ genomes enables the pursuit of numerous objectives aimed at enhancing crop quality and yield. This involves breeding plants to have desirable compositional features and characteristics that provide resistance to a range of biotic and abiotic stressors.