The widespread usage of electronic devices has surged in recent decades, leading to frequent device failures primarily due to inadequate thermal management. To address these issues, heat pipes (HP) have been implemented in electronic devices. This paper investigates the use of novel graphene nanofluids in HP for electronic cooling applications. The graphene nanofluid is synthesized and injected into HP. The study discusses the effects of graphene nanofluids on improving the performance of HP compared to deionized water. The impact of an orientation on thermal performance of the HP, with input parameters including 40 W input power, inclination angles of 0°, 45°, and 90° and a 50% filling ratio. Key performance metrics such as thermal resistance, temperature difference between the evaporator and condenser, and thermal conductivity are assessed. Results demonstrates that the thermal performance of the HP improves with increasing inclination angle, exhibiting the lowest thermal resistance and highest thermal conductivity at a 90° inclination, in comparison to 45° and 0° angles. Conversely, the highest thermal resistance is achieved at a 0° orientation. These findings suggest that a 90° inclination angle is optimal for electronic cooling applications.