By improving soil health and promoting crop growth, nanomaterials can significantly enhance sustainable agricultural production, bolster global food security, and support environmental conservation efforts. Numerous case studies from various regions worldwide, including Europe, the USA, Asia, and Africa, have demonstrated the substantial potential of nanomaterials in addressing challenges in modern farming. These challenges include managing soil health and improving crop growth across diverse agroecological contexts. Despite the abundance of studies on this topic, comprehensive analyses summarizing the most successful case studies on the application of nanomaterials in promoting soil health and crop growth are still lacking and require further updates. To bridge this knowledge gap, this chapter presents top successful case studies from various regions, highlighting the practical applications of nanomaterials in improving soil health and crop growth.