The objective of this study is to analyze the factors that cause maternal deaths and the effect of medications given to reduce them in Karnataka. To carry out this work, 3 years data (2017–2020) is collected from the Official Karnataka government website (Health Management System) which describes both maternal and infant health and causes of deaths district-wise in Karnataka. Maternal data is extracted and analyzed by grouping the districts into 4 administrative divisions. A linear regression process is used for selecting the relevant factors. Overall maternal deaths decreased by 0.09% from 2017 to 2020, with significant increases seen in Bengaluru Urban (0.189%), Bijapur (0.356%), and Yadgir (0.07%), and notable decreases in Belagavi (0.495%), Gulbarga (0.415%), and Dharwad (0.138%). Bengaluru Urban recorded the highest deaths (83) in 2019–20. Factors contributing to maternal deaths include severe Anemia (p = 0.9999), GDM (p = 0.962), and obstetric complications (p = 0.02). Districts with high mortality rates also had spikes in severe Anemia, GDM, and obstetric complications, while districts like Bengaluru Rural, Hassan, Uttar Kannada, and Shivamogga saw reduced mortality rates. Interestingly, these districts also showed a reduction in severe anemia and gestational diabetes mellitus (GDM) cases. Based on the analysis, it can be concluded that addressing the treatment of anemia, reducing the prevalence of GDM, and effectively managing obstetric complications are crucial steps toward achieving the goal of a maternal mortality rate.