This chapter explores the critical field of humanitarian logistics and supply chain management, focusing on its unique challenge in managing disruptions, innovative solutions, and theoretical underpinnings. As humanitarian crises become increasingly complex and frequent, the need for resilient and adaptive supply chains has never been more pressing. The research explores various types of disruptions affecting humanitarian supply chains, from natural disasters to man-made crises, and analyzes effective intervention strategies to mitigate their impact. The chapter highlights innovative approaches leveraging cutting-edge technologies such as artificial intelligence, blockchain, and additive manufacturing to enhance the agility and effectiveness of humanitarian supply chains. A comprehensive review of relevant past provides a theoretical foundation for understanding disruption management in humanitarian contexts. By synthesizing current knowledge and identifying future research directions, this work contributes to the ongoing development of more efficient and effective humanitarian logistics systems, ultimately aiming to improve the delivery of aid to those in need during crises.