India’s urban areas, hosting 34% of the population, are vital for economic growth. However, climate change-induced heat islands threaten urban rivers, causing flooding. Mumbai’s Mithi River exemplifies this issue. To address it, measures were taken after the 2005 deluge. Two phases of river development works were initiated as per the Hon. Bombay High Court’s proposal. Expert institutions and studies contributed to urban planning, enhancing resilience. Infrastructure projects like the Metro Rail and environmental initiatives served as adaptation measures. Regular desilting of the river was crucial. Community engagement and awareness campaigns fostered responsibility. Stakeholders, including government agencies, NGOs, and local communities, played pivotal roles. These collective efforts have effectively prevented similar floods since 2005, safeguarding productivity. Mumbai’s experience underscores the importance of holistic, sustainable solutions for urban development. Proactive river rejuvenation initiatives promote long-term sustainability, ensuring urban communities’ well-being and prosperity.