With a growing incidence in the aging population, neurodegenerative disorders like Alzheimer’s and Parkinson’s disease present serious challenges to world health. The therapeutic potential of natural chemicals, especially flavonoids and carotenoids, in slowing the advancement of these crippling diseases has drawn increasing attention in recent years. Widely found in fruits, vegetables, and drinks, flavonoids are known for their anti- inflammatory, neuroprotective, and antioxidant qualities. A growing body of research indicates that flavonoids affect important pathways connected to neurodegenerative processes, such as the suppression of inflammation, oxidative stress, and protein misfolding. Furthermore, their potential as neuroprotective agents is increased by their capacity to traverse the blood-brain barrier. Renowned for their antioxidant properties and function as precursors to vitamin A, carotenoids have also gained traction as possible neuroprotective agents. Carotenoids have anti-inflammatory actions and affect signaling pathways related to neuronal survival in addition to their antioxidant qualities. The variety of sources of carotenoids and flavonoids, their bioavailability, and the status of clinical research at this time demonstrate their effectiveness in treating Parkinson’s and Alzheimer’s disease. This chapter will discuss the possible advantages of a comprehensive mechanism approach in the prevention of neurodegenerative diseases, as well as the synergistic effects of mixing flavonoids and carotenoids. In addition, the difficulties of conducting clinical trials like finding particular drugs with the best therapeutic potential and standardizing dosages are covered.