This chapter explores the integration of AI and blockchain technologies in healthcare and how their combined use can revolutionize the industry. AI, with its powerful data analytics capabilities, enhances decision-making and predictive accuracy, while blockchain ensures secure, transparent, and tamper-proof data management. The chapter covers various applications of AI in healthcare, such as diagnostics, personalized medicine, and patient monitoring, and highlights how blockchain enhances data integrity and security in these scenarios. Through case studies, examples, and critical evaluations, the chapter demonstrates the potential of combining these technologies to address current challenges in healthcare, such as data privacy, interoperability, and clinical trial integrity.