The genus Bidens, comprising numerous species distributed across diverse habitats globally, has been a subject of botanical interest due to its ecological significance and medicinal properties. This chapter offers an in-depth exploration of recent advances in Bidens genomics, integrating findings from genome sequencing, comparative genomics, and functional analyses. Genomic studies have offered insights into Bidens evolutionary history, genetic diversity, and adaptive mechanisms. Variations in genome size and structure, coupled with the genetic basis of adaptive traits such as herbivore defense and stress tolerance, highlight the role of gene duplication and horizontal gene transfer in driving evolutionary innovation. Comparative genomics sheds light on phylogenetic relationships and speciation events within Bidens, while population genomics reveals patterns of genetic diversity and demographic history. The integration of genomic data with traditional botanical knowledge holds great promise for various applications. These include improving agricultural productivity, advancing drug discovery, and enhancing strategies for managing ecosystems. By utilizing genomic resources such as high-quality reference genomes and detailed gene expression profiles, researchers can lead focused breeding programs to make crops more resilient and increase yields, even in the face of worsening climate conditions and growing pest challenges. Moreover, genomic-guided approaches facilitate the sustainable utilization of Bidens medicinal compounds for drug discovery and healthcare applications.