Handloom weaving plays an important role in the livelihood generation of the women weavers. The commercial weavers in the handloom weaving units perform the weaving activities, such as picking, battening and shedding operations where they are found to assume awkward postures and repetitions at work. Although the weavers vary in anthropometric measurements, the looms used for commercial weaving are mostly of the same size. These anthropometric variations in the weavers created discomfort while sitting in the loom where the shorter height weavers exert more force for movement of the treadle whereas taller height weavers lack enough room for movement of the treadle. In the long run, these awkward postures raise various health-related problems where the occupational health of the weavers is at risk. To mitigate these problems in the weaving industry and ensure the well-being of the workers, the present study aims to develop a predictive regression model for designing a comfortable seat height for the loom for the occupational well-being of commercial weavers. Three different parameters were used to measure the comfortability of the improved loom. Results showed a significant decrease in the percentage of EMG (RMS) value in the muscles (gastrocnemius muscle and rectus femoris muscle) from the existing loom. A significant reduction in the angle of deviation was found. The reduction in body pain was observed in the improved loom at lower back (31.39%) followed by upper back (24.88%), leg (22.22%), neck (21.85%) and knee (20.21%).