Technology is rapidly transforming the business landscape. This has changed the global work environment. Today’s workforce is diverse regarding culture, demography, and physical characteristics. Human well-being has a direct correlation with business success. This paper explores how ergonomics is important in achieving physical, mental, and emotional well-being for the task force to focus on sustainability for Industry 5.0. The future of business depends on the technological innovations. With ergonomic principles carefully implemented, technologies can be easily integrated into the workplace. As the Internet of Things, extended reality, and artificial intelligence become commonplace in the industry, ergonomics is pivotal in improving the work experience. By reducing the physical and cognitive load, potential health risks are reduced. When an organization places human well-being at the top of its priority list, it creates an environment of trust, respect, and values that leads to sustainable success.