This autoethnographic investigation delves into the transformative journey of ergonomic practices within hospital settings, spotlighting the shift from a rehabilitation-oriented approach to a scalable macroergonomic paradigm. Through meticulous exploration of personal experiences and reflections from a clinical outpatient occupational therapy practice in Northern California spanning from 1994 to 2003, this study elucidates the metamorphosis of ergonomic methodologies and their profound implications on employee well-being, patient care quality, and hospital operational efficiency. Employing the autoethnographic qualitative research method, this research probes into the intricate interplay between the experiences of injured workers in acute and subacute hospital settings and the systems devised in response to ergonomic risk factors. These discerned trends and patterns paved the way for the adoption of a macroergonomic strategy in employee injury prevention. The findings underscore the paramount importance of comprehending and mitigating causative and interacting factors that influence personal health resources, resilience, and status among individuals in need of care. The progressive steps outlined in this case study encompassed the advocacy for widespread macroergonomic approaches, effectively ameliorating the risk of repetitive strain injuries in demanding work environments within acute and subacute care hospitals. The seamless integration of macroergonomics into the hospital’s operational framework engendered the development of sustainable employee health practices and amplified back-end supportive functions and efficiencies. Ultimately, these paradigm shifts resulted in cost savings for the hospital, improved employee well-being, and enhanced patient care delivery.