The present work focuses on manual cashew kernel-separating activity in small-scale cashew mills in Andhra Pradesh state of India. The main objective of the study is to minimize ergonomic risk and musculoskeletal discomfort among cashew kernel-separating workers. The prevalence of work-related musculoskeletal disorders (MSDs) was determined using a questionnaire. The data were collected from twenty-five cashew kernel-separating workers. Among the study respondents, 96% of the workers experienced the prevalence of MSDs during the past 12 months. Most workers (84%) reported lower back pain as their main problem. Based on these observations, an ergonomic workstation was designed and developed. Design criteria were established for the development of workstation design through participatory discussions. The prototype workstation was tested against the adopted posture and compared with existing conditions. Additionally, the self-perceived discomfort among cashew kernel workers was measured using five-point rating scale. Based on the evaluation, the study findings demonstrated that the developed prototype workstation could reduce MSD risk among cashew kernel-separating workers. In a nutshell, this study highlights the benefits of low-cost ergonomic intervention in small-scale cashew industries.