As organizations seek to incorporate new technology and accommodate a growing variety of work patterns, organizations today face numerous issues in maintaining the performance and wellness of their workforces. In modern offices, it is easy to witness the paradigm shift in office workers’ lifestyles from an active to a sedentary one. On average, office computer users sit still at their desks for 6 to 12 h daily. The employees’ health has suffered significantly as a result. The study was conducted to shed light on the many health issues that office workers are experiencing because of the office environment and workplace design in contemporary workplaces. A total of ten government office workers from the Department of Science and Technology in Occidental Mindoro, Philippines were interviewed, observed and answered the survey. The results revealed that the factor that affects most the cognitive strains of the workers that have a negative impact on them are: the work is boring the office is noisy and the office equipment. Regression results also revealed that the cognitive strains have a significant relationship with age, employment status, and height. The RULA also showed that the current working position of the workers has a high risk with a score of seven risk index. Aligning with RULA results, office workers experienced different body pains, especially in the neck, shoulders and wrist/hands, preventing them from carrying out normal activities. The result of this study can be a basis for a better work design for management worldwide.