This study examines the evolving nature of family caregiving in the twenty-first century, with a focus on contemporary trends affecting caregivers. It explores the complex interactions between macro-social trends, societal perceptions, and technological advancements that shape caregiving experiences. The research highlights key challenges faced by over 40 million unpaid caregivers in the United States, such as the impact of globalization, digitalization, and changing views on disability and inclusion. Using a systematic literature review and a qualitative analysis, the study identifies significant stressors for caregivers, including physical, psychological, and economic burdens. It also emphasizes the potential of innovative technological solutions to alleviate these challenges. The findings underscore the need for comprehensive support systems and interventions to improve caregivers’ well-being and suggest that future research should focus on developing integrated frameworks to better support caregivers in a rapidly changing world.