Fe41Co7Cr15Mo14Y2C15B6 bulk metallic glass (BMG) with a diameter of 4 mm was prepared by water-cooled copper mold suction method. The amorphous structure and thermodynamic parameters of the as-cast alloy were characterized using X-ray diffraction (XRD) and differential scanning calorimetry (DSC), respectively. Compression deformation of the amorphous alloy was performed using a Gleeble 3500 thermal simulator at 620 ℃ with a strain rate of 1 × 10−2 s−1 in the supercooled liquid region to study the effect of deformation (20, 40, and 75%) on the structure and thermal stability of the amorphous alloy. Results show that the amorphous samples exhibit good plastic deformation without significant crystallization under these conditions. With increasing plastic deformation, the thermal stability of the amorphous alloy improves. When the strain is 75%, the glass transition temperature and supercooled liquid region width increase from 585 ℃ to 40 ℃ in the as-cast state to 658 ℃ and 59 ℃, respectively. Deformation affects the microhardness of the amorphous samples, with higher strain resulting in higher microhardness. The highest Vickers hardness values for plastic strains of 20%, 40%, and 75% are 1258, 1270, and 1288 HV, respectively.