The development of floating wind turbines requires precise analysis of the mooring system’s response. Previous methods were unable to fully capture the coupled interaction between anchor, chain, and seabed in the integrated analysis of floating wind turbines. This paper presents a numerical formulation to evaluate the dynamic interaction among the seabed, anchors, mooring lines, floating support structure, and a full-scale floating wind turbine. The anchor-chain-seabed interaction is modeled using macro-models, which represent the non-linear relationship between incremental displacements and soil reaction forces along the mooring line in contact with the seabed. This approach also describes the interaction between the seabed and two specific types of anchors-suction caisson and fluke anchors-based on the macro-model framework. By incorporating these macro-models into simulations of the dynamic response of floating wind tur-bines, uncertainties in anchor design can be minimized. Furthermore, this approach allows for optimization of the mooring system design by accounting for seabed influence, ultimately reducing overall costs. This model also enables efficient evaluation of seabed trench formation resulting from repeated mooring line movements. An example is provided to demonstrate the application of this integrated analysis method for floating wind turbines, highlighting the necessary parameters for implementation.