Transitioning from fossil fuels to non-carbon fuels is essential in pursuing carbon neutrality. A gradual combination of natural gas and hydrogen could offer a smooth shift and reduce potential energy distribution and heating source disruptions. Academic institutions, industry, and governments worldwide actively support hydrogen mixing projects such as “HyDeploy”, “GRHYD”, “THyGA”, and Hy Blend to develop effective pathways to reduce carbon emissions. To successfully commercialize hydrogen blending, it is crucial to make scientific advancements and conduct a favorable techno-economic analysis. Current studies are centered around gaining a deeper understanding of methane-hydrogen mixtures. Researchers are examining various properties of these mixtures, including “density, phase interactions, viscosity, and energy densities”. The goal is to comprehend better how these properties affect massive transportation through pipeline networks and their uses in various industries. It is crucial to balance safety concerns, such as overpressure and leakage in pipelines, and hydrogen’s non-carbon energy carrier advantages. Techno-economic models are now being developed to gain insights into energy transportation efficiency and accurately estimate the cost of delivering hydrogen-blended natural gas as we transition to cleaner energy systems. This review highlights significant global initiatives to boost confidence in the shift toward methane-hydrogen gas blends, which serve as a stepping stone toward the widespread implementation of a hydrogen-based economy by 2050.