Application of membrane technology in treatment high fouling solutions where the standard cross-flow modules become inoperative was effectively continued with a new class of filtration device known as Dynamic Shear Enhanced Membrane Filtration Pilots (DSEMFPs). As the name suggest, all DSEMFPs operate on the principle of shear-induced solute scoop up from the membrane surface. Multi-Shaft Disk (MSD) and Intermeshed Spinning Basket Membrane (ISBM) pilots are the two most advanced designs of DSEMFP group that largely enriched the state-of-the art in terms of maximum specific filtration area and inbuilt cleaning facility, respectively. In spite of several performance characterization studies on MSD and ISBM, no hydrodynamic analysis was undertaken to the best of our knowledge, which might have served as the baseline information to formulate suitable scale-up relations. In this article, we have presented the outcomes of CFD simulations of MSD and ISBM using realizable \(k - \varepsilon\) turbulent model and Rotating Reference Frame (RRF). Rotational speed was found to have dominant effects on different hydrodynamic profiles compared to the transmembrane pressure. Moreover, most of the hydrodynamic variables (e.g., turbulent kinetic energy, turbulent KE dissipation rate, vorticity, shear rate, velocity magnitude, and shear stress) were noted to increase with the rotational velocity with non-uniform spatial profile over the membrane surface. We apprehend that the outcomes of our investigation will significantly influence the scale-up study of the aforementioned DSEMFPs.