Microfluidics governs droplet and microliter-volume fluids. In biotechnology, clinical diagnostics, soil health monitoring, water pollutants detection, and healthcare, it is used for its precision, cheap cost, and speed. Personalized suggestions leverage microfluidics systems for accurate decisions. The microchannels of microfluidic devices are produced in a clean laboratory using expensive chemicals and sophisticated prototyping procedures that discouraged from entering this sector. Laser cut acrylic, puffy paint, printed circuit board, and 3D printing were used to make microfluidic channels. As an alternative to high-end oxygen plasma equipment, flame plasma and corona treatment can activate surfaces that improves device to substrate bonding. Visual inspection and leakage testing are crucial to device inspection. The constructed devices were leakage tested and advised to limit flow to 4 ml/mi. Our investigation suggests laser cut and PCB molds with flame plasma bonding for low-end lab infrastructures.