With the increase in exchanges between mainland China and Macao, an increasing number of Macao students choose to study mainland China. This study, which analyzes the unique needs of Macao students studying in mainland China in terms of national education conditions, explores the feasibility and effectiveness of education informatization in addressing these needs. This article first summarizes the basic status of Macao students studying in mainland China and the importance of national education conditions and then analyzes the unique needs of Macao students in terms of national education conditions on the basis of the data. On the basis of briefly explaining the distinctive strengths of education informatization, this study proposes recommendations to meet the unique needs of Macao students for national education conditions through education informatization to provide a helpful reference for improving national education conditions for Macao students.