An efficient two-stage voltage multiplier-equipped high-step-up voltage-multiplier interleaved SEPIC converter using model predictive controller for renewable applications is presented in this paper. The main intention of this work is to integrate the combined benefits of both two stage interleaved converter with voltage multiplier and model predictive controller for attaining a steady state voltage. Single stage DC-DC converter in open loop system faces challenges in achieving precise output with varying inputs. Hence, closed loop control is used. Two Stage High Gain DC-DC Converters with Model Predictive Control (MPC) is designed for renewable applications. The proposed system addresses the limitations of existing converters, and the proposed system has improved efficiency, dynamic response. Closed-loop voltage multiplier control of a voltage multiplier and high step-up interleaved SEPIC converter employing PI and Model Predictive Controlled (MPC) have been simulated and the responses of simulated Model Predictive Controlled (MPC) systems are compared with respect to steady state error and settling time. The outcomes of the simulation show that Model Predictive Controlled interleaved SEPIC converter gives superior to PI controlled interleaved SEPIC converter in terms of time domain response. In a two-stage high step-up converter system, the model predictive controller performs better than the closed-loop PI controller. An input voltage of 15 V with source disturbance is converted to a constant output voltage of 125 V by the high step-up interleaved SEPIC converter with voltage multiplier, which has a voltage gain of 8.33.