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In this contribution, the characteristics and anticancer activity of chromium (Cr) doped Fe3O4 nanoparticles, of the form Fe2+(Fe3+0.95Cr3+0.05)2O4, with 0 < x < 0.05 is discussed. The Cr-doped Fe3O4 nanoparticles were synthesized using the green synthesis method, employing extract derived from the Krantz aloe (Aloe arborescens) plant that is indigenous to Southern Africa. For comparison, undoped Fe3O4 nanoparticles were also prepared in a similar fashion, as to study the impact of the Cr doping on the impact of the compounds’ anticancer activities. Characterization, done using x-ray diffraction (XRD), confirmed the nanoparticles’ purity and crystalline nature. Transmission electron microscopy (TEM) gives particle sizes of 18 ± 1 nm and 6 ± 1 nm for the Fe3O4 and Cr-doped Fe3O4, respectively. Magnetic characterization indicates the ferrimagnetic behaviour of the particles. Fourier-transform infrared spectroscopy (FTIR) is used to probe the bonding environment of the ions. The results of cell viability assays proves that the green synthesized Fe3O4 and Cr-doped Fe3O4 nanoparticles exhibited anticancer activity when tested against colorectal adenocarcinoma (DLD-1) cells; as well as the ability to destroy more cancerous cells compared to healthy human embryonic kidney (HEK-293) cells. Present results indicate that the Cr-doped Fe3O4 nanoparticles were smaller in size and showed enhanced anticancer activity when compared to the undoped Fe3O4 nanoparticles.

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Targeting Colorectal Cancer Using Krantz Aloe (Aloe arborescens) Extract Green Synthesised Chromium Doped Fe3O4 Nanoparticles

  • 会议论文

  • 发表日期：

    2025年

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  • Shobana Nagaraj,
  • Carlo Berrino,
  • Aletta Prinsloo,
  • Pankaj Mohanty,
  • Ramesh Pandian,
  • Clement Penny,
  • Charles Sheppard

摘要

In this contribution, the characteristics and anticancer activity of chromium (Cr) doped Fe3O4 nanoparticles, of the form Fe2+(Fe3+0.95Cr3+0.05)2O4, with 0 < x < 0.05 is discussed. The Cr-doped Fe3O4 nanoparticles were synthesized using the green synthesis method, employing extract derived from the Krantz aloe (Aloe arborescens) plant that is indigenous to Southern Africa. For comparison, undoped Fe3O4 nanoparticles were also prepared in a similar fashion, as to study the impact of the Cr doping on the impact of the compounds’ anticancer activities. Characterization, done using x-ray diffraction (XRD), confirmed the nanoparticles’ purity and crystalline nature. Transmission electron microscopy (TEM) gives particle sizes of 18 ± 1 nm and 6 ± 1 nm for the Fe3O4 and Cr-doped Fe3O4, respectively. Magnetic characterization indicates the ferrimagnetic behaviour of the particles. Fourier-transform infrared spectroscopy (FTIR) is used to probe the bonding environment of the ions. The results of cell viability assays proves that the green synthesized Fe3O4 and Cr-doped Fe3O4 nanoparticles exhibited anticancer activity when tested against colorectal adenocarcinoma (DLD-1) cells; as well as the ability to destroy more cancerous cells compared to healthy human embryonic kidney (HEK-293) cells. Present results indicate that the Cr-doped Fe3O4 nanoparticles were smaller in size and showed enhanced anticancer activity when compared to the undoped Fe3O4 nanoparticles.