Due to the issues of vibration and secondary structural noise caused by the introduction of high-speed railway into airport GTC (Ground Traffic Center), GTC is a comprehensive ground traffic center that integrates railways, subways, aviation, bus, etc. three different high-speed railway main line introduction schemes are proposed. By establishing a three-dimensional coupled model for numerical analysis, the vehicle-induced vibration response of different schemes is compared, and the optimal scheme is selected. The results show that: (1) the frequency of GTC vehicle-induced vibration caused by high-speed railway operation is concentrated in 30–80 Hz, and the vibration in the propagation process of bridge-pile-soil-GTC, the vibration in the frequency range of 30–200 Hz decays rapidly, and the low frequency vibration in the range of 10–20 Hz is amplified.(2) when the high-speed railway is introduced by three schemes of bridge and common plate, bridge-built separation, bridge and roadbed, the maximum vibration level of the commercial area reaches 82.0 dB, 70.2 dB, 73.3 dB respectively, and the vibration exceedance rate of bridge-built separation scheme is the lowest and the maximum secondary structural noise reaches 43.2 dB(A), 33.1 dB(A), 38.5 dB(A) respectively, only the secondary structural noise of the bridge-built separation scheme meets the requirements. (3) using vehicle-induced vibration and secondary structural noise as evaluation criteria, the optimal solution for introducing a 350 km/h high-speed railway into the GTC is bridge-built separation.