Fibrous Cortical Defect/Non-ossifying Fibroma
摘要
Fibrous cortical defect (FCD) is an ephemeral small benign lesion of fibroblastic proliferation which is limited to cortex in younger children. FCD is mostly less than 3 cm in maximum dimension [1]. Nonossifying fibroma (NOF) is a larger-sized, common nonneoplastic benign fibrogenic lesion eccentrically involving the medulla in older children or adolescents. NOF is considered as a larger version (>3–5 cm) of FCD. These lesions are histologically identical and thought to be not neoplasm but a group of developmental abnormalities related to dysfunctional ossification. Most NOF is single, but multifocal NOFs may be occasionally presented, and rarely found in the setting of the Jaffe-Campanacci syndrome (multiple NOFs of considerable size, café au-lait spots, mental retardation, hypogonadism, cryptorchidism, ocular/cardiovascular anomalies, or skin alterations) [2–4].