Salinity significantly hampers crop production by disrupting water and nutrient uptake in plants, which leads to reduced yields and diminished soil fertility. Plant growth-promoting bacteria (PGPB) can be used as a long-term strategy for reducing the negative effects of salinity by producing phytohormones, ACC deaminase, osmolytes, ROS scavenging enzymes, exopolysaccharides, and salicylic acid. Phytohormones play a crucial role in this stress response by controlling several aspects of plant growth and adaptability. Abscisic acid activates stress-responsive genes and induces stomatal closure to reduce water loss. Auxins promote root initiation and elongation while cytokinins maintain the balance between root and shoot growth by cell division. ACC deaminase-producing PGPB mitigates inhibitory effects of ethylene under salinity stress, while osmolytes and ROS scavenging maintain cellular homeostasis. Exopolysaccharides protect roots from dehydration, and salicylic acid enhances salt tolerance by improving ion balance, boosting antioxidative responses, and activating the defense pathways. The chapter highlights the potential of PGPB as a promising approach to improve crop resilience in saline conditions by highlighting key biochemical and physiological mechanisms. The necessity of combining PGPB-mediated approaches with traditional farming methods is an effective way of achieving long-term salinity mitigation and ensuring sustainable agriculture.