Climate change is an international issue with profound consequences for multiple components of the ecosystem, including the usage and fate of pesticides, posing significant challenges to agricultural systems and ecosystem health. Pesticides are frequently employed to manage pests in the agricultural and public health sectors, but their use, efficacy, frequency of applications, transport, movement, degradation processes, and persistence in the environment are influenced by climate-related factors, including temperature increases, elevated CO2 concentrations, and precipitation patterns. The objective of this chapter is to investigate how pesticide use and environmental fate are impacted by climate change. The effects of climate change on pesticide usage and fate have important implications for environmental contamination, ecological effects, and human health. Understanding these effects is critical to identifying the possible risks of pesticide usage and establishing appropriate mitigation and adaptation strategies. The knowledge gathered from this brief overview can assist in addressing the complicated challenges caused by climate change and reducing the detrimental impact of pesticide use on the environment. The necessity of taking proactive steps to lessen the negative effects is generally highlighted in this chapter, which also explores the significance of implementing integrated pest management (IPM) practices, developing pesticide formulations that are climate-resilient, incorporating climate change considerations into pesticide policy and regulations, and promoting organic and precision agriculture approaches.