Sesuvium portulacastrum (L.) L. has gained significant attention in recent times owing to its remarkable adaptability to high salinity environments and its potential for various ecological and industrial applications. One interesting aspect of Sesuvium portulacastrum lies in its associated microbiome, which plays a pivotal role in its survival and growth in challenging environments. These microbes thrive under high salinity conditions and aid in nutrient acquisition and overall plant health. This chapter aims to explore the microbial diversity associated with S. portulacastrum and explain the prospects and opportunities that arise from this unique plant-microbe interaction. A comprehensive analysis of recent studies highlight the diverse range of microorganisms, including bacteria, archaea, fungi, and algae, which thrive in association with S. portulacastrum. The potential applications of this microbiome include bioremediation, bioprospecting for novel bio-compounds, plant growth-promoting traits, and the development of resilience in food crops. The capacity of these microbes to enhance soil quality, reduce environmental pollutants, and promote crop growth under saline conditions shows promising opportunities for ecological restoration and economic development. They can also play a vital role in various ecological processes, such as nitrogen fixation, organic matter decomposition, and the enhancement of soil structure and biodiversity. Understanding and harnessing the microbial diversity of Sesuvium portulacastrum provide insights into its ecological significance and potential applications for ecosystem restoration and conservation. This also opens opportunities for research and innovation, offering sustainable solutions to the challenges posed by saline environments and environmental degradation.