Marine pollution is a global issue that coincides with the escalation in anthropogenic activity. Among the most concerning pollutants are plastic debris, organic and inorganic chemicals, and radionuclides. These pollutants are problematic due to their recalcitrant, toxicity, and long distant transport. The hazardous nature of these pollutants necessitates effective remediation strategies. Numerous solutions have been introduced to combat marine pollution, from chemical to biological agents. Bioremediation, either through human interference or natural occurrence, emerges as a viable technique to resolve the marine pollution issue cost-efficient and environmentally friendly ways. Marine bioremediation strategies, in general, have implemented biostimulation and bioaugmentation approach. Moreover, the biology agents, in removing the pollutants, may employ bioaccumulation, bioreduction, biomineralization, and biodegradation approach. This chapter discusses marine pollution, that is, plastic, organic, inorganic pollution, and radionuclides. In addition, this chapter discusses the existing bioremediation strategies designated to mitigate these pollutions, highlighting their mechanisms, effectiveness, and potential for optimization in real-world application. In laboratory experiment, it is feasible to optimize bioremediation outcomes, for example, achieving complete removal (100% degradation) of organic pollutant. However, implementing bioremediation in actual marine environment poses additional challenges, necessitating collaborative efforts among academia, industry, government is demanding to achieve a sustainable remediation approach.