Present work is focused on the investigation of shear layer atomization of thin film of mucosalivary fluid in the presence of unsteady pulsed airflow mimicking cough events. The fluid dynamics of thin film atomization is numerically studied, and a comparison is made between two flow cases, namely laminar and LES turbulence modeling approach. In the initial stage, the deformation of the thin liquid film in shear flow shows qualitative similarity, and a prominent wavy Kelvin-Helmholtz instability-like structure is observed to form in results obtained using both the approaches. Whereas, in the later stage, deformation of liquid film into bag-like structure due to pulsed air velocity was observed to appear with LES approach, unlike laminar approach. Overall, it is observed that investigation of the liquid film atomization using LES approach has provided relatively better insights such as inflation of deformed liquid film into bag like structure, its rupture and fragmentation into tiny-sized droplets compared to that of laminar approach, which are essential and important aspects in the physics of coughing phenomena.