An automobile radiator is an important component of an automotive cooling system that have an intricate design and is crucial in transporting heat from the engine’s internal components to the outside air. This study presents a performance analysis of an automotive radiator using Al2O3 and CuO nanoparticles as coolants, conducted solely through simulation using the Ansys software. We have calculated and compared the heat transfer coefficients of mixture of Al2O3, CuO and water with nanofluid. Nanofluid preparation is done using 0.15 and 0.3% concentration Al2O3 and 0.15 and 0.3% concentration CuO, remaining using water and glycol having equal proportion. The objective of this study is to evaluate the impact of these nanoparticles on the thermal characteristics and heat transfer properties of the radiator. It was observed that nanofluid having CuO nanoparticles shows higher heat transfer coefficient than the others. A three- dimensional computational model of the automotive radiator was developed in SolidWorks and analyzed in Ansys Fluent.