Large-size molybdenum matrix composites (Mo-CCN-ZrO2) with a diameter of 50 mm are prepared by using a forging manner to meet the demand for large-size, high-strength, and challenging molybdenum matrix composites for hot-end components of aerospace equipment. The effects of quite a number of forging deformations on the organization and properties of large-size molybdenum matrix composites are systematically investigated. The findings demonstrate that large-size molybdenum matrix composites strengthened by rapid forging deformation performance have been improved, with the increase of deformation. Mechanical properties show a trend of first increase and then decrease. In the deformation amount of 58%, the performance reaches the maximum, the densification is 99.9%, tensile strength is 726 MPa, flexural strength is 1, 639 MPa, and fracture toughness is 30.2 MPa·m1/2. The preparation of a molybdenum matrix composite material nozzle has burnout resistance and a molybdenum-based composite material nozzle has good ablation resistance with a line ablation rate of 0.002 mm/s.